Jaeok Park Selected Research

farnesyl pyrophosphate (farnesyl diphosphate)

1/2020	Phosphonate and Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthases: A Structure-Guided Perspective.
1/2019	Inhibition of farnesyl pyrophosphate (FPP) and/or geranylgeranyl pyrophosphate (GGPP) biosynthesis and its implication in the treatment of cancers.
7/2014	Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases.
10/2013	Thienopyrimidine bisphosphonate (ThPBP) inhibitors of the human farnesyl pyrophosphate synthase: optimization and characterization of the mode of inhibition.
4/2012	Design and synthesis of active site inhibitors of the human farnesyl pyrophosphate synthase: apoptosis and inhibition of ERK phosphorylation in multiple myeloma cells.

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Jaeok Park Research Topics

Disease

4	Bone Resorption 01/2020 - 12/2012
3	Neoplasms (Cancer) 01/2019 - 12/2012
2	Multiple Myeloma 08/2018 - 04/2012
2	Bone Diseases (Bone Disease) 01/2017 - 01/2014
1	Christianson Type Syndromic X-Linked Mental Retardation 01/2020
1	Carcinogenesis 01/2019
1	Hypercholesterolemia 01/2019
1	Neoplasm Metastasis (Metastasis) 01/2019
1	Osteoporosis 01/2019
1	Neurodegenerative Diseases (Neurodegenerative Disease) 07/2014

Drug/Important Bio-Agent (IBA)

5	farnesyl pyrophosphate (farnesyl diphosphate)IBA 01/2020 - 04/2012
4	Diphosphonates (Bisphosphonates)IBA 08/2018 - 12/2012
1	AlkaliesIBA 01/2020
1	Protons (Proton)IBA 01/2020
1	EnzymesIBA 01/2020
1	CationsIBA 01/2020
1	Terpenes (Terpenoids)IBA 01/2019
1	GTP Phosphohydrolases (GTPases)IBA 01/2019
1	geranylgeranyl pyrophosphate (geranylgeranyl diphosphate)IBA 01/2019
1	thienopyrimidineIBA 08/2018
1	Geranylgeranyl-Diphosphate GeranylgeranyltransferaseIBA 08/2018
1	NitrogenIBA 01/2017
1	Pharmaceutical PreparationsIBA 07/2014
1	LigandsIBA 07/2014
1	prenylIBA 01/2014
1	Monomeric GTP-Binding ProteinsIBA 10/2013
1	Proteins (Proteins, Gene)FDA Link 10/2013

Therapy/Procedure

1	Therapeutics 12/2012